.alpha.1-proteinase inhibitor human
.alpha.1-proteinase inhibitor human is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| glassia | Biologic Licensing Application | 2010-12-20 |
| prolastin-c | Biologic Licensing Application | 2009-10-31 |
| zemaira | Biologic Licensing Application | 2010-09-29 |
Indications
FDA
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Agency Specific
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ATC Codes
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Clinical
Clinical Trials
214 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alpha 1-antitrypsin deficiency | D019896 | — | E88.01 | 28 | 45 | 14 | 7 | 42 | 117 |
| Emphysema | D004646 | EFO_0000464 | J43 | — | 9 | 3 | 4 | 12 | 27 |
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | 1 | 7 | 5 | 6 | 23 |
| Pulmonary emphysema | D011656 | — | J43 | — | 7 | 3 | 2 | 10 | 21 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 2 | 1 | 2 | 12 | 17 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | 2 | 1 | 2 | 11 | 16 |
| Obstructive lung diseases | D008173 | — | — | — | 1 | 1 | 2 | 11 | 15 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 3 | 5 | 2 | 1 | — | 10 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 2 | 3 | 2 | 7 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | 2 | 2 | 1 | 6 |
Show 16 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 2 | 4 | 3 | — | 4 | 12 |
| Leukemia | D007938 | — | C95 | 1 | 5 | 4 | — | — | 8 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 5 | 4 | — | — | 8 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | 5 | 4 | — | — | 8 |
| Covid-19 | D000086382 | — | U07.1 | — | 2 | 1 | — | 4 | 7 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | 5 | 3 | — | 1 | 7 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 1 | — | 1 | 3 |
| Coronary disease | D003327 | — | — | — | — | 2 | — | 1 | 3 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | — | 1 | 2 | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | 2 | — | — | 3 |
Show 34 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | 1 | 4 | — | — | 8 | 13 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 4 | 7 | — | — | — | 9 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | 4 | — | — | 4 | 9 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | — | — | 3 | 5 |
| Syndrome | D013577 | — | — | 1 | 3 | — | — | 2 | 5 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 2 | — | — | 3 | 5 |
| Cerebral hemorrhage | D002543 | — | — | — | 2 | — | — | 2 | 4 |
| Acute kidney injury | D058186 | — | N17 | — | 1 | — | — | 1 | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | 2 | 3 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | 1 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | 1 | 2 |
| Sleep deprivation | D012892 | — | F51.12 | 2 | — | — | — | — | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Neuromyelitis optica | D009471 | EFO_0004256 | G36.0 | 1 | — | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | — | — | — | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | — | — | — | 4 | 4 |
| Pulmonary fibrosis | D011658 | — | J84.10 | — | — | — | — | 4 | 4 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 2 | 2 |
| Argininosuccinic aciduria | D056807 | — | — | — | — | — | — | 2 | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 2 | 2 |
| Cholestasis | D002779 | — | K83.1 | — | — | — | — | 2 | 2 |
| Alagille syndrome | D016738 | EFO_0004151 | Q44.71 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
Show 50 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | .alpha.1-proteinase inhibitor human |
| INN | — |
| Description | .alpha.1-proteinase inhibitor human is a protein pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Protein |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297879 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
Target
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Variants
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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7,979 adverse events reported
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